Page 55 - 2020世界青年科学家峰会总结册

KEYNOTE SPEECHES

2011 年，学界普遍认为这些新近发现了数以万计的长链非编码 RNA 分子，他们在外形上就像已知的编码
RNA 一样，含有长长的尾巴。但是在庞大的基因组暗物质中是不是存在新型的非编码 RNA 分子家族？
面向世界科技前沿的核糖核酸 RNA 领域，我带领团队潜心研究，创建了新的研究体系，努力寻找他们的
代谢规律和功能机制。

过去近十年里，我们在理论上揭示了哺乳动物转录组的复杂性和非编码 RNA 的多样性及重要功能，开拓
了多个非编码 RNA 研究的新方向。这些工作也为更好地理解细胞增殖和天然免疫调控，认识小胖威利征
和红斑狼疮等疾病提供 RNA 方向的创新思路和理论框架，具有临床转化前景。未来，关于非编码 RNA
功能机制及应用研究，必将惠及于人民的生命和健康。

In 2011, it's widely believed in the academic community that the newly discovered tens of
thousands of long non-coding RNA molecules contained long tails, just like the known coding
RNAs in shape. But is there a new family of non-coding RNA molecules in the huge "genomic dark
matter"? Targeting the ribonucleic acid (RNA) at the forefront of science and technology, I've led a
team to study intensively and we've built a new research system as we try to find their metabolic
rules and functional mechanism.

In the last nearly ten years, we have theoretically revealed the complexity of transcriptomes and
the diversity and important functions of non-coding RNAs in mammals and explored a number
of new directions for non-coding RNA research. These have also provided innovative ideas and
theoretical frameworks in the direction of RNA for better understanding cell proliferation and
innate immune regulation and learning more about such diseases as Prader-Willi Syndrome and
lupus erythematosus, representing a promising prospect in clinical transformation. Going forward,
studies on the non-coding RNA functional mechanism and application are bound to benefit
people's lives and health.

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